Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

Athuluri-Divakar, Sai Krishna; Vasquez-Del Carpio, Rodrigo; Dutta, Kaushik; Baker, Stacey J; Cosenza, Stephen C; Basu, Indranil; Gupta, Yogesh K; Reddy, M V Ramana; Ueno, Lynn; Hart, Jonathan R; Vogt, Peter K; Mulholland, David; Guha, Chandan; Aggarwal, Aneel K; Reddy, E Premkumar.

Cell ; 165(3): 643-55, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-27104980

2.

A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.

Baker, Stacey J; Cosenza, Stephen C; Athuluri-Divakar, Saikrishna; Reddy, M V Ramana; Vasquez-Del Carpio, Rodrigo; Jain, Rinku; Aggarwal, Aneel K; Reddy, E Premkumar.

Mol Cell ; 79(1): 180-190.e4, 2020 07 02.

Artigo em Inglês | MEDLINE | ID: mdl-32619468

3.

B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.

Baker, Stacey J; Ma'ayan, Avi; Lieu, Yen K; John, Premila; Reddy, M V Ramana; Chen, Edward Y; Duan, Qiaonan; Snoeck, Hans-Willem; Reddy, E Premkumar.

Proc Natl Acad Sci U S A ; 111(8): 3122-7, 2014 Feb 25.

Artigo em Inglês | MEDLINE | ID: mdl-24516162

4.

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

Gumireddy, Kiranmai; Reddy, M V Ramana; Cosenza, Stephen C; Boominathan, R; Boomi Nathan, R; Baker, Stacey J; Papathi, Nabisa; Jiang, Jiandong; Holland, James; Reddy, E Premkumar.

Cancer Cell ; 7(3): 275-86, 2005 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-15766665

5.

CDK4: a master regulator of the cell cycle and its role in cancer.

Baker, Stacey J; Poulikakos, Poulikos I; Irie, Hanna Y; Parekh, Samir; Reddy, E Premkumar.

Genes Cancer ; 13: 21-45, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36051751

6.

TGFß reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis.

Xia, Yuhan; Inoue, Kazuki; Du, Yong; Baker, Stacey J; Reddy, E Premkumar; Greenblatt, Matthew B; Zhao, Baohong.

Nat Commun ; 13(1): 3920, 2022 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-35798734

7.

Understanding the temporal sequence of genetic events that lead to prostate cancer progression and metastasis.

Baker, Stacey J; Reddy, E Premkumar.

Proc Natl Acad Sci U S A ; 110(37): 14819-20, 2013 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-23995446

8.

Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.

Sato, Katsutoshi; Padgaonkar, Amol A; Baker, Stacey J; Cosenza, Stephen C; Rechkoblit, Olga; Subbaiah, D R C Venkata; Domingo-Domenech, Josep; Bartkowski, Alison; Port, Elisa R; Aggarwal, Aneel K; Ramana Reddy, M V; Irie, Hanna Y; Reddy, E Premkumar.

Nat Commun ; 12(1): 4671, 2021 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-34344863

9.

p89c-Myb is not required for fetal or adult hematopoiesis.

Baker, Stacey J; Kumar, Atul; Reddy, E Premkumar.

Genesis ; 48(5): 309-16, 2010 May.

Artigo em Inglês | MEDLINE | ID: mdl-20196078

10.

Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia.

Baker, Stacey J; Cosenza, Stephen C; Ramana Reddy, M V; Premkumar Reddy, E.

Oncotarget ; 10(20): 1932-1942, 2019 Mar 08.

Artigo em Inglês | MEDLINE | ID: mdl-30956775

11.

Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.

Padgaonkar, Amol; Rechkoblit, Olga; Vasquez-Del Carpio, Rodgrigo; Pallela, Venkat; Venkata Subbaiah, Drc; Cosenza, Stephen C; Baker, Stacey J; Ramana Reddy, M V; Aggarwal, Aneel; Reddy, E Premkumar.

Oncotarget ; 9(102): 37753-37765, 2018 Dec 28.

Artigo em Inglês | MEDLINE | ID: mdl-30701029

12.

Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb.

Kumar, Atul; Baker, Stacey J; Lee, Clement M; Reddy, E Premkumar.

Mol Cell Biol ; 23(18): 6631-45, 2003 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-12944488

13.

Small unstable apoptotic protein, an apoptosis-associated protein, suppresses proliferation of myeloid cells.

Baker, Stacey J.

Cancer Res ; 63(3): 705-12, 2003 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-12566317

14.

Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).

Reddy, M V Ramana; Akula, Balireddy; Cosenza, Stephen C; Athuluridivakar, Saikrishna; Mallireddigari, Muralidhar R; Pallela, Venkat R; Billa, Vinay K; Subbaiah, D R C Venkata; Bharathi, E Vijaya; Vasquez-Del Carpio, Rodrigo; Padgaonkar, Amol; Baker, Stacey J; Reddy, E Premkumar.

J Med Chem ; 57(3): 578-99, 2014 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-24417566

15.

CDK4: A Key Player in the Cell Cycle, Development, and Cancer.

Baker, Stacey J; Reddy, E Premkumar.

Genes Cancer ; 3(11-12): 658-69, 2012 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23634254

16.

Targeted inhibition of kinases in cancer therapy.

Baker, Stacey J; Reddy, E Premkumar.

Mt Sinai J Med ; 77(6): 573-86, 2010.

Artigo em Inglês | MEDLINE | ID: mdl-21105121

17.

Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.

Jatiani, Shashidhar S; Baker, Stacey J; Silverman, Lewis R; Reddy, E Premkumar.

Genes Cancer ; 1(10): 979-93, 2010 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-21442038

18.

A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.

Jatiani, Shashidhar S; Cosenza, Stephen C; Reddy, M V Ramana; Ha, Ji Hee; Baker, Stacey J; Samanta, Ajoy K; Olnes, Matthew J; Pfannes, Loretta; Sloand, Elaine M; Arlinghaus, Ralph B; Reddy, E Premkumar.

Genes Cancer ; 1(4): 331-45, 2010 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-20717479

19.

A role for Cdk4 in angiogenesis.

Baker, Stacey J.

Cell Cycle ; 9(13): 2493, 2010 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-20647754

20.

A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance.

Gumireddy, Kiranmai; Baker, Stacey J; Cosenza, Stephen C; John, Premila; Kang, Anthony D; Robell, Kimberly A; Reddy, M V Ramana; Reddy, E Premkumar.

Proc Natl Acad Sci U S A ; 102(6): 1992-7, 2005 Feb 08.

Artigo em Inglês | MEDLINE | ID: mdl-15677719

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A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.

B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

CDK4: a master regulator of the cell cycle and its role in cancer.

TGFß reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis.

Understanding the temporal sequence of genetic events that lead to prostate cancer progression and metastasis.

Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.

p89c-Myb is not required for fetal or adult hematopoiesis.

Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia.

Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.

Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb.

Small unstable apoptotic protein, an apoptosis-associated protein, suppresses proliferation of myeloid cells.

Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).

CDK4: A Key Player in the Cell Cycle, Development, and Cancer.

Targeted inhibition of kinases in cancer therapy.

Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.

A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.

A role for Cdk4 in angiogenesis.

A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance.